A Finnish 27-year follow-up study suggests that common oral infections in childhood, caries and periodontal diseases, are associated with an increased risk of atherosclerosis in adulthood.
The study was initiated in 1980, when clinical oral examinations were conducted for 755 children aged 6, 9, and 12 years. The follow-up ended in 2007, when the carotid artery intima-media thickness was measured in an ultrasound examination of participants, who were then 33, 36, and 39 years old.
The follow-up was 27 years, and cardiovascular risk factors were measured at several time points. A cumulative exposure to the risk factor was calculated in both childhood and adulthood. The signs of oral infections and inflammation collected in the study included caries, fillings, bleeding on probing, and probing pocket depth.
The more signs of oral infections, the higher the risk for atherosclerosisFrom all children, 68%, 87%, and 82% had bleeding, caries, and fillings, respectively. There were no differences between the boys and the girls. Slight periodontal pocketing was observed in 54% of the children, and it was more frequent in the boys than in the girls. Only 5% of the examined mouths were totally healthy, whereas 61% and 34% of the children had one to three signs and four signs of oral infections, respectively.
“The number of signs associated significantly with the cumulative exposure to the cardiovascular risk factors in adulthood, but especially in childhood,” says professor Markus Juonala from the University of Turku.
Both caries and periodontal diseases in childhood were significantly associated with carotid artery intima-media thickness in adulthood. Thickening of the carotid artery wall indicates the progression of atherosclerosis and an increased risk for myocardial or cerebral infarction.
Information source: https://www.helsinki.fi/en/news/health-news/childhood-caries-and-periodontal-diseases-may-increase-the-risk-of-atherosclerosis-in-adulthood